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SML0445 Sigma

Clemastine fumarate salt

≥98% (HPLC)

Synonym: (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt, (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt, 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt, 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt, Meclastine fumarate salt, Mecloprodine

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Properties

Related Categories Antagonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology,
InChI Key   PMGQWSIVQFOFOQ-YKVZVUFRSA-N
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D +15 to +25°, c = 1 in methanol
storage condition   desiccated
color   white to beige
solubility   DMSO: 5 mg/mL (clear solution; warmed)
storage temp.   room temp

Description

Packaging

100 mg in glass bottle

Biochem/physiol Actions

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
UY0704600

Documents

Certificate of Analysis


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Protocols & Articles

Articles

Histamine Receptors

The biogenic amine histamine plays an important role in a variety of pathophysiological conditions. In peripheral tissues, histamine is mainly stored in mast cells and basophils. In allergic conditio...
Keywords: Alzheimer Disease, Atomic absorption spectroscopy, Cardiovascular, Clinical, Diseases, Gene expression, Inflammation, Ligands, Neurotransmitters, Obesity, Transduction

Peer-Reviewed Papers
15

References

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