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SML0471 Sigma

A22 hydrochloride

≥95% (HPLC)

Synonym: MreB Perturbing Compound A22, S-(3,4-Dichlorobenzyl)isothiourea hydrochloride

  • CAS Number 22816-60-0

  • Empirical Formula (Hill Notation) C8H8Cl2N2S · HCl

  • Molecular Weight 271.59

  •  MDL number MFCD00035050

  •  PubChem Substance ID 329825427

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Properties

Related Categories A-AM, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   VBJNMXMOMSWRDV-UHFFFAOYSA-N
assay   ≥95% (HPLC)
form   powder
color   white to beige
solubility   H2O: 2 mg/mL (clear solution, warmed)
storage temp.   2-8°C

Description

Packaging

10, 50 mg in glass bottle

Application

A22 hydrochloride has been used to study its anti-biofilm activity, antibacterial, cyto and genotoxic activities. It is also used as a MreB polymerization inhibitor to understand the role of MreB polymers in Candidatus Thiosymbion oneisti and Candidatus T. hypermnestrae division.

Biochem/physiol Actions

A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been shown to act as an antiobiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport. A22 has been shown to have synergistic effects with several antibiotics including novobiocin and rifampin in gram negative bacteria.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


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