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SML0508 Sigma

Pentostatin

≥95% (HPLC)

Synonym: (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, 2′-dCF, DCF, Deoxycoformycin

  • CAS Number 53910-25-1

  • Empirical Formula (Hill Notation) C11H16N4O4

  • Molecular Weight 268.27

  •  PubChem Substance ID 329825517

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Properties

Related Categories Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
InChI Key   FPVKHBSQESCIEP-JQCXWYLXSA-N
assay   ≥95% (HPLC)
form   powder
optical activity   [α]/D +70 to +80°, c = 1 in H2O
storage condition   desiccated
color   white to beige
solubility   H2O: 10 mg/mL, clear
shipped in   wet ice
storage temp.   −20°C

Description

Other Notes

Air sensitve; hygroscopic.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Pentostatin is a ring-expanded nucleoside (REN) that potently inhibits adenosine deaminase, which leads to lymphocyte toxicity. Pentostatin is used as anticancer agent to treat leukemia (hairy cell leukemia and chronic lymphocytic leukemia) and is investigated as an agent to treat graft-versus-host disease (GVHD).

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis


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Protocols & Articles

Articles

Adenosine Receptors

There are four known subtypes of adenosine receptors, referred to as A1, A2A, A2B and A3. All are members of the superfamily of G protein-coupled receptors and each bears the characteristic motif of ...
Keywords: Atomic absorption spectroscopy, Cancer, Cardiovascular, Diabetes, Diseases, Gene expression, Inflammation, Magnetic resonance spectroscopy, Neurotransmitters, Substitutions, Transduction

Peer-Reviewed Papers
15

References

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