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SML1106 Sigma-Aldrich

Ryanodine

≥98% (HPLC)

Synonym: Ryanodol 3-(1H-pyrrole-2-carboxylate)

  • CAS Number 15662-33-6

  • Empirical Formula (Hill Notation) C25H35NO9

  • Molecular Weight 493.55

  •  PubChem Substance ID 329825481

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Intracellular Calcium Regulators,
biological source   Ryania speciosa
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   DMSO: 10 mg/mL, clear
shipped in   wet ice
storage temp.   −20°C
SMILES string   O=C(O[C@@H]1[C@](O)(C(C)C)[C@@]([C@@]2(O)O3)(C)[C@@]4(O)[C@]1(O)[C@](C2)(C)[C@]5(O)[C@]43[C@H](O)[C@@H](C)CC5)C6=CC=CN6
InChI   1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19-,20-,21-,22+,23+,24+,25+/m0/s1
InChI key   JJSYXNQGLHBRRK-YSOSZROBSA-N

Description

Biochem/physiol Actions

Ryanodine is a potent regulator of intracelluar calcium release from sarcoplasmic reticulum (SR) in the ER of cardiac and striated muscle. At nanomolar concentrations, Ryanodine locks the ryanodine receptors (RyRs) in a half-open state causing release of calcium, while at higher (~100 MicroMolar) concentrations, Ryanodine irreversibly inhibits channel-opening.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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