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SML1290 Sigma-Aldrich

PA-824

≥98% (HPLC)

Synonym: (6S)- 6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-Imidazo[2,1-b][1,3]oxazine, (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, (S)-PA 824, PA 824, Pretomanid

  • CAS Number 187235-37-6

  • Empirical Formula (Hill Notation) C14H12F3N3O5

  • Molecular Weight 359.26

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D -40 to -48°, c = 1 in methanol
color   white to brown
solubility   DMSO: 5 mg/mL, clear (warmed)
storage temp.   −20°C
InChI   1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1
InChI key   ZLHZLMOSPGACSZ-NSHDSACASA-N

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

PA-824 is a pro-drug that has an effect on both replicating and non-replicating Mycobacterium tuberculosis. It is activated by deazaflavin (cofactor F420)-dependent nitroreducase.

PA-824 is an anti-tuberculosis drug that exhibits multiple mechanism of action, including both cell wall inhibition and respiratory poisoning.

PA-824 is an anti-tuberculosis drug.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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