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SML1849 Sigma-Aldrich

TP-064 TFA salt

≥98% (HPLC)

Synonym: N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide trifluoroacetate salt

  • Empirical Formula (Hill Notation) C28H34N4O2 · CF3CO2H

  • Molecular Weight 572.62

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to brown
solubility   DMSO: 10 mg/mL, clear
shipped in   wet ice
storage temp.   −20°C
SMILES string   O=C(N(CC1=CC(C2CCN(CCNC)CC2)=NC=C1)C)C3=CC=CC(OC4=CC=CC=C4)=C3.FC(F)(C(O)=O)F

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

TP-064 is a selective chemical probe for protein arginine methyltransferase 4 (PRMT4) developed out of a collaborative effort by Takeda and the SGC. TP-064 inhibited PRMT4 with an IC50 value < 10 nM for methylation of H3 (1-25). It showed greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In cellular assays, TP-064 inhibited the methylation of MED12 with an IC50 value of 43 nM. For full characterization details, please visit the TP-064 probe summary on the Structural Genomics Consortium (SGC) website.

TP-064N is the negative control for the active probe, TP-064. To request a sample of the negative control from the SGC, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Features and Benefits

TP-064 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Gene Regulation

The loss of regulation of gene expression is a key component to many human disease states, including neurodegenerative disorders, autoimmune conditions and, most prominently, cancers. Regulation of g...
Keywords: Acetylations, Epigenetics, Gene expression, Genomics, Methylations, PAGE, Post translational modifications, Transcription

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