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SML1992 Sigma-Aldrich

FM-479

≥98% (HPLC)

Synonym: (E)-2-Cyano-3-(5-(1-cyclohexyl-6-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide, 2-Cyano-3-(5-(1-cyclohexyl-6-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide, FM-381 Inactive Control

  • Empirical Formula (Hill Notation) C25H26N6O2

  • Molecular Weight 442.51

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, F
assay   ≥98% (HPLC)
form   powder
color   yellow to orange
solubility   DMSO: 2 mg/mL, clear
storage temp.   2-8°C
SMILES string   CN(C(/C(C#N)=C/C(O1)=CC=C1C2=NC3=CN=C(N(C)C=C4)C4=C3N2C5CCCCC5)=O)C

Description

Biochem/physiol Actions

FM-479 is an FM-381 structural analog that exhibits no inhibitory potency against JAK3 or other kinases when used at the FM-381 effective dosing range of 100-300 nM. For characterization details of the active probe, FM-381, please visit the FM-381 probe summary on the Structural Genomics Consortium (SGC) website.

FM-381, the active probe, is available from Sigma. To learn more about and purchase FM-381, click here.

To learn about other SGC chemical probes, visit sigma.com/sgc

Features and Benefits

FM-479 is a negative control for FM-381, a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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