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SML2220 Sigma-Aldrich

SGC-AAK1-1N

≥98% (HPLC)

Synonym: N-(6-(3-(Cyclopropanesulfonamido)phenyl)-1H-indazol-3-yl)isobutyramide, SGC-AAK1-1 Negative Control

  • Empirical Formula (Hill Notation) C20H22N4O3S

  • Molecular Weight 398.48

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, S
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 2 mg/mL, clear
storage temp.   2-8°C
SMILES string   O=C(C(C)C)NC1=NNC2=C1C=CC(C3=CC(NS(C4CC4)(=O)=O)=CC=C3)=C2

Description

Biochem/physiol Actions

SGC-AAK1-1N is a structure analog of and the recommended negative control for SGC-AAK1-1 (AAK1 IC50 = 11 μM and 270 nM, respectively, by coupled enzyme assay; KD = 8.8 μM/AAK1 & >10 μM/BIKE with SGC-AAK1-1N vs. KD = 26 nM/AAK1 & 930 nM/BIKE with SGC-AAK1-1). For characterization details of the active probe, SGC-AAK1-1, please visit the SGC-AAK1-1 probe summary on the Structural Genomics Consortium (SGC) website.

SGC-AAK1-1, the active probe, is available from Sigma. To learn more about and purchase SGC-AAK1-1, click here.

To learn about other SGC chemical probes, visit sigma.com/sgc

Features and Benefits

SGC-AAK1-1N is a negative control for SGC-AAK1-1, a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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