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T1698 Sigma-Aldrich

Tetradecylthioacetic acid

≥97% (NMR)

Synonym: TTA

  • Linear Formula C14H29-S-CH2COOH

  • Molecular Weight 288.49

  •  MDL number MFCD00128230

  •  PubChem Substance ID 24278726

  •  NACRES NA.77

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Properties

Related Categories Antitumor Agents, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cancer Research, Cell Biology,
Quality Level   100
assay   ≥97% (NMR)
color   white
solubility   DMSO: soluble ≥22 mg/mL
SMILES string   CCCCCCCCCCCCCCSCC(O)=O
InChI   1S/C16H32O2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-15-16(17)18/h2-15H2,1H3,(H,17,18)
InChI key   IPBCWPPBAWQYOO-UHFFFAOYSA-N
Gene Information   human ... PPARA(5465)

Description

Packaging

5 mg in glass bottle

Biochem/physiol Actions

PPARα agonist; activation in ranking order: PPARδ > PPARα > PPARγ

Tetradecylthioacetic acid (TTA) is known to modulate lipid homeostasis. TTA can increase fatty acid oxidation and ketogenesis, which can subsequently prevent adiposity and insulin resistance. Furthermore, TTA can enhance cardiac functions during experimental heart failure.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Packaged under nitrogen.

Preparation Note

Tetradecylthioacetic acid is soluble in DMSO at a concentration that is greater than or equal to 22 mg/ml.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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