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T2830 Sigma

Tomatine hydrate

≥95% (HPLC)

Synonym: Lycopersicin, NSC 234440, NSC 9223, Spirosolane, a-Tomatine, alpha-tomatine, b-D-galactopyranoside deriv

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Properties

Related Categories Apoptosis Inducers, Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience
assay   ≥95% (HPLC)
form   powder
color   white to off-white
solubility   DMSO: >20 mg/mL
storage temp.   room temp

Description

Preparation Note

Tomatine hydrate is soluble in DMSO at a concentration that is greater than 20 mg/ml.

Application

Tomatine has been used as a standard for HPLC-based determination of tomatine from red and green tomatoes1. It has also been used to study its teratogenic effect using frog embryos2.

Biochem/physiol Actions

When the pure compounds were isolated, alpha-Tomatine was highly effective in inhibiting all of the cell lines, whereas dehydrotomatine, tomatidenol, and tomatidine had little, if any, effect on cell inhibition. It had been previously shown that commercial tomatine, which is customarily an approximate 10:1 mixture of α-tomatine and dehydrotomatine, strongly inhibits the growth of both colon and liver cancer cells.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Cellstream flow cytometry

Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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