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T2952 Sigma

Tetrabenazine

≥98% (HPLC), solid

Synonym: 9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-3-isobutyl-2H-benzo[a]quinolizin-2-one

  • CAS Number 58-46-8

  • Empirical Formula (Hill Notation) C19H27NO3

  • Molecular Weight 317.42

  •  Beilstein Registry Number 40090

  •  EC Number 200-383-6

  •  MDL number MFCD08461052

  •  PubChem Substance ID 329826731

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   MKJIEFSOBYUXJB-GDBMZVCRSA-N
assay   ≥98% (HPLC)
form   solid
solubility   DMSO: >10 mg/mL
  H2O: insoluble
originator   Roche
storage temp.   2-8°C

Description

Packaging

10, 50 mg in glass bottle

Preparation Note

Tetrabenazine is soluble in DMSO at a concentration that is greater than 10 mg/ml and is insoluble in water.

Application

Tetrabenazine has been used for dopamine uptake assays in mouse brain cells1. Tetrabenazine has also been used for non-specific binding assays in postnuclear supernatants derived from PC-12 and CV-1 cells2.

Biochem/physiol Actions

Tetrabenazine is a reversible type 2 vesicular monoamine transporter (VMAT) inhibitor. It depletes dopamine stores.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
DK2275000

Documents

Certificate of Analysis


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Protocols & Articles
Peer-Reviewed Papers
15

References

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