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T4887 Sigma

T-2 Toxin

from Fusarium sp., powder, ≥98% (HPLC)

Synonym: 12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol-4,15-diacetate-8-isovalerate, 4β,15-Diacetoxy-3α-hydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene

  • CAS Number 21259-20-1

  • Empirical Formula (Hill Notation) C24H34O9

  • Molecular Weight 466.52

  •  Beilstein Registry Number 3575695

  •  EC Number 244-297-7

  •  MDL number MFCD00871255

  •  PubChem Substance ID 24900234

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Mold, Nitric Oxide and Cell Stress,
biological source   Fusarium sp.
InChI Key   BXFOFFBJRFZBQZ-QYWOHJEZSA-N
assay   ≥98% (HPLC)
form   powder
availability   not available in Japan
  not available in USA
color   white
solubility   chloroform: soluble 9.80-10.20 mg/mL, clear, colorless to faintly yellow
  DMSO: freely soluble
  petroleum ether: slightly soluble
storage temp.   −20°C

Description

Preparation Note

T-2 Toxin is soluble in chloroform at 9.80 - 10.20 mg/ml and yields a clear, colorless to faint yellow solution. Furthermore, the product is freely soluble in DMSO and slightly soluble in petroleum ether.

Quality

Chromatographically purified

Application

T-2 toxin can cause degenerative lesions in articular cartilage of rats8. Furthermore, immunotoxicity studies have reported that T-2 toxin can cause cell death in human lymphoid T cells and also induces cell membrane damage in B cells9.

Biochem/physiol Actions

The trichothecenes, such as T2 Toxin, are mycotoxins produced by fungi of the genus Fusarium. They are commonly present in foods and feed of cereal origin. T-2 toxin induces DNA damage and cell death on prolonged administration. These effects can be partially blocked by antioxidants, such as glutathione, coenzyme Q10, or α-tocopherol. Increases blood-brain barrier permeability and inhibits monoamine oxidase activity in brain.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN3462 - class 6.1 - PG 1 - Toxins, extracted from living sources, solid, n.o.s., HI: all (not BR)
WGK Germany 
3
RTECS 
YD0100000

Documents

Certificate of Analysis

Certificate of Origin


Milli-Q® Water Purification Solutions
Protocols & Articles

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Peer-Reviewed Papers
15

References

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