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T7205 Sigma

Tegafur

≥98% (HPLC), powder

Synonym: 5-Fluoro-1-(tetrahydro-2-furyl)uracil, Ftorafur, Tegafur

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   WFWLQNSHRPWKFK-UHFFFAOYSA-N
assay   ≥98% (HPLC)
  ≥98% (HPLC)
form   powder
color   white to off-white
mp   171-173 °C(lit.)
solubility   DMSO: >50 mg/mL
storage temp.   room temp

Description

Packaging

5, 25 mg in glass bottle

Preparation Note

Tegafur is soluble in DMSO at a concentration that is greater than 50 mg/ml.

Application

Tegafur has been used as an internal standard for the analysis of 5′DFCR (5′deoxyfluorocytidine) and 5′DFUR (5′deoxyfluorouridine) using HPLC techniques. Tegafur has also been used as an internal standard for the chromatographic assay of azidothymidine (AZT).

Biochem/physiol Actions

Tegafur is a pro-drug of 5-fluorouracil, an antimetabolite used as an antineoplastic agent. It has been used as adjuvant chemotherapy for curatively resected colorectal cancer therapy.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3

Documents

Certificate of Analysis


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