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B8936 Sigma-Aldrich

Betulinic acid

≥98% (HPLC)

Synonym: 3β-Hydroxy-20(29)-lupaene-28-oic acid, Lupatic acid, Mairin

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Isoprenoids, Lipids, Nutrition Research,
assay   ≥98% (HPLC)
mp   295-298 °C (dec.) (lit.)
storage temp.   2-8°C
SMILES string   CC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(O)=O
InChI   1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23-,24+,27-,28+,29+,30-/m0/s1
InChI key   QGJZLNKBHJESQX-FZFNOLFKSA-N

Description

Application

Betulinic acid (BetA), a pentacyclic triterpene anticancer candidate, may be used to study its function and activity as an activator of mitochondrial pathway apoptosis involving p53- and CD95-independent mechanisms. Betulinic acid is used to study its potential cardiovascular role in the modulation of endothelium-dependent relaxation.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Betulinic acid, a pentacyclic triterpene, selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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