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C9754 Sigma

Colchicine

≥95% (HPLC), powder

Synonym: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide

  • CAS Number 64-86-8

  • Empirical Formula (Hill Notation) C22H25NO6

  • Molecular Weight 399.44

  •  Beilstein Registry Number 2228813

  •  EC Number 200-598-5

  •  MDL number MFCD00078484

  •  PubChem Substance ID 24278348

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Properties

Related Categories Antitumor Agents, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cancer Research,
InChI Key   IAKHMKGGTNLKSZ-INIZCTEOSA-N
assay   ≥95% (HPLC)
form   powder
color   white to yellow
mp   150-160 °C (dec.)(lit.)
solubility   ethanol: 50 mg/mL
Gene Information   human ... ABCB1(5243), CYP3A4(1576)
mouse ... Abcb1a(18671), Abcb1b(18669)

Description

Packaging

1, 5 g in poly bottle

100, 500 mg in poly bottle

Biochem/physiol Actions

Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1544PSN1 6.1 / PGI
WGK Germany 
3
RTECS 
GH0700000

Documents

Certificate of Analysis

Certificate of Origin


LC-MS Grade Solvents and Reagents

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for ADME/Tox

A significant number of drugs that fail in clinical trials have been associated with safety issues, including unexpected drug-drug interactions (DDI) or lack of efficacy due to poor pharmacokinetics....
Keywords: Absorption, Bioactive small molecules, Clinical, Metabolism

Novel and Rapid Method to Assess Proliferative Properties of Mammalian Cells by Monitoring Cell Size Distributions

Much research has recently focused on elucidating the mechanisms by which eukaryotic cells regulate their size with respect to growth rate and cell cycle stage. These mechanisms are known to differ b...
Keywords: Apoptosis, Cell culture, Cell proliferation, Flow cytometry, High performance liquid chromatography, Sample preparations

Using Global Reach to Source and Deliver Critical Plant Breeding Chemicals

For many crops, colchicine is used to produce doubled haploids, enabling homozygosity in a single generation. When used, this process enables seed development companies to deliver better-performing v...
Keywords: Agriculture

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Agriculture | Crop Protection Workflow

Pesticides are an essential component in modern agriculture and enable growers to fully realize the yield potential of their seeds. From compound discovery to active ingredient development, our chemi...
Keywords: Agriculture, Building blocks, Gas chromatography, Gas chromatography mass spectrometry, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Organic synthesis, Pesticides, Polymerase chain reaction - quantitative, Purification, Solvents

Peer-Reviewed Papers
15

References

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