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1349706 USP

Isoniazid

United States Pharmacopeia (USP) Reference Standard

Synonym: 4-Pyridinecarboxylic acid hydrazide, INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide

  • CAS Number 54-85-3

  • Empirical Formula (Hill Notation) C6H7N3O

  • Molecular Weight 137.14

  •  Beilstein/REAXYS Number 119374

  •  MDL number MFCD00006426

  •  PubChem Substance ID 329750199

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards I - K More...
InChI Key   QRXWMOHMRWLFEY-UHFFFAOYSA-N
mp   171-173 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
storage temp.   2-8°C

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.

Sales restrictions may apply.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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PHR1932 Isoniazid, Pharmaceutical Secondary Standard; Certified Reference Material

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