EMAIL THIS PAGE TO A FRIEND
1491332 USP

Paclitaxel

United States Pharmacopeia (USP) Reference Standard

  • CAS Number 33069-62-4

  • Empirical Formula (Hill Notation) C47H51NO14

  • Molecular Weight 853.91

  •  Beilstein/REAXYS Number 1420457

  •  MDL number MFCD00869953

  •  PubChem Substance ID 329750652

  •  NACRES NA.24

Purchase

Properties

Related Categories Analytical Standards, Analytical/Chromatography, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards P - R More...
InChI Key   RCINICONZNJXQF-MZXODVADSA-N
mp   213 °C (dec.) (lit.)
Featured Industry   Pharmaceutical (small molecule)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).

Caution

Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.

Sales restrictions may apply.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

HPLC Analysis of Taxols on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Taxols on Ascentis® Express F5
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical, Separation

Related Products

related product

Product #

Description

Add to Cart

PHR1803 Paclitaxel, Pharmaceutical Secondary Standard; Certified Reference Material
08168 Timestrip Plus 8 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?