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1612561 USP

Sildenafil citrate

United States Pharmacopeia (USP) Reference Standard

Synonym: 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate salt, 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-one citrate salt, Revatio, Sildenafil citrate salt, UK-92,480

  • CAS Number 171599-83-0

  • Empirical Formula (Hill Notation) C22H30N6O4S ·C6H8O7

  • Molecular Weight 666.70

  •  MDL number MFCD09026931

  •  PubChem Substance ID 329751094

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Description

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

USP issued SDS can be found here.

Biochem/physiol Actions

Sildenafil is a potent, selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5). Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension. NO activates guanylate cyclase, which results in increased levels of cGMP, producing smooth muscle relaxation. Sildenafil enhances the effect of NO by inhibiting PDE5, which is responsible for degradation of cGMP.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Related Substances of Sildenafil Citrate (USP)

Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. In 1994, Pfizer filed a patent covering the use of ...
Keywords: High performance liquid chromatography

Sildenafil Citrate USP Method Using HPTLC Plates for the Limit of Imidazole Test

Sildenafil, sold under the brand name Viagra, among others, is a medication that can be used as a selective inhibitor of cyclic GMP- specific photodiesterase (type V) with vasodilator action. It can ...
Sanjay Poman
Merck KGaA, Darmstadt, Germany, Life Science Application Centre (GAC), Mumbai, India
Keywords: Thin layer chromatography

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PHR1807 Sildenafil Citrate, Pharmaceutical Secondary Standard; Certified Reference Material
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