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1612700 USP

Simvastatin

United States Pharmacopeia (USP) Reference Standard

  • CAS Number 79902-63-9

  • Empirical Formula (Hill Notation) C25H38O5

  • Molecular Weight 418.57

  •  MDL number MFCD00072007

  •  PubChem Substance ID 329751099

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites,
InChI Key   RYMZZMVNJRMUDD-HGQWONQESA-N
form   neat
mp   127-132 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Simvastatin is a specific inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. It is used in the treatment of hypercholesterolemia, as it reduces levels of low-density lipoproteins and triglycerides, and raises high-density lipoprotein levels. Simvastatin is a lactone that is readily hydrolyzed in vivo to the corresponding β-hydroxyacid, and can be activated prior to use with NaOH in EtOH treatment. It is a synthetic analog of lovastatin (Cat. No. M2147).

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.

Sales restrictions may apply.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Statins on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Statins on Ascentis® RP-Amide
Keywords: Chromatography, Clinical, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

Related Products

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Description

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PHR1438 Simvastatin, Pharmaceutical Secondary Standard; Certified Reference Material
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