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105171 Sigma-Aldrich

5-Methoxy-2-methyl-3-indoleacetic acid

98%

Synonym: 2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetic acid, N-Des(4-chlorobenzoyl)indomethacin, NSC 97026

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Properties

Related Categories Building Blocks, C12, Chemical Synthesis, Heterocyclic Building Blocks, Indoles More...
InChI Key   TXWGINUZLBAKDF-UHFFFAOYSA-N
assay   98%
mp   161-163 °C (lit.)
solubility   methanol: soluble

Description

General description

5-Methoxy-2-methyl-3-indoleacetic acid is hydrolysis product of indomethacin.

Application

• Reactant for preparation of antimalarial agents
• Reactant for preparation of ndomethacin analogs as cyclooxygenase and lipoxygenase inhibitors with antiinflammatory activity
• Reactant for preparation of [123I]-indomethacin derivatives as COX-2 targeted imaging agents
• Reactant for preparation of histone deacetylase inhibitors
• Reactant for preparation of 2,N6,5′-substituted adenosine derivatives as ligands for A2B adenosine receptor
• Reactant for preparation of prostaglandin D2 receptor antagonist

5-Methoxy-2-methyl-3-indoleacetic acid was used for quantitative determination of indomethacin and its major impurities in suppository and capsule formulations by HPLC. 5-Methoxy-2-methyl-3-indoleacetic acid was used in a study to develop fast, sensitive and simultaneous determination of metabolites of serotonin using liquid chromatography with mass spectrometric detection.

Packaging

1, 5 g in glass bottle

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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