12072 Sigma-Aldrich



  • CAS Number 618-39-3

  • Linear Formula C6H5C(=NH)NH2

  • Molecular Weight 120.15

  •  Beilstein/REAXYS Number 606020

  •  EC Number 210-546-3

  •  MDL number MFCD00042826

  •  PubChem Substance ID 57646968



Related Categories Building Blocks, Chemical Synthesis, Imines & Amidines, Nitrogen Compounds - Organic Building Blocks, Organic Building Blocks More...
Quality Level   200
assay   ≥95.0%
form   powder or crystals
SMILES string   NC(=N)c1ccccc1
InChI   1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9)
Gene Information   human ... F10(2159), F2(2147), PLAT(5327), PLAU(5328), PLG(5340), PRSS1(5644)



Benzamidine was used in the preparation of heparan sulfate-rich proteoglycan from mouse mammary epithelial cells. It has been used to prevent enzymatic degradation during the purification procedure of bovine factor XII (Hageman factor).


10, 50 g in glass bottle

Biochem/physiol Actions

Benzamidine is an inhibitor of plasmin and has been used in the radioimmunoassay of glucagon in human plasma. It prevents the destruction of Thyrotropin-releasing hormone (TRH) added to whole blood in vitro before radioimmunoassay of TRH.

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What solvents can be used to dissolve Benzamidine, Product 12072?
Based on our experience with this compound in quality control, we would expect it to be soluble in methanol (0.5g in 10mL of methanol).
The buffer preparation protocol calls for benzamidine. Should I use the free base or the hydrochloride hydrate salt?
It is possible that either the benzamidine or the benzamidine hydrochloride hydrate could work for your application. The major difference will be that the benzamidine hydrochloride hydrate (Product No. B6506) is expected to dissolve easier in aqueous solutions. Neither Product 12072 nor the salt Product B5606 is molecular biology, cell culture or biotechnology certified, so their performance once dissolved is likely to be similar.
What is the solution stability of Benzamidine, Product 12072?
Sigma-Aldrich does not perform formal solution stability testing on this material; however, it is expected to be sensitive to oxidation. It is recommended to prepare solutions fresh for each use.
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