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125180 Sigma-Aldrich

1-(3-Chlorophenyl)piperazine hydrochloride

99%

Synonym: m-CPP

  • CAS Number 65369-76-8

  • Empirical Formula (Hill Notation) C10H13ClN2 · xHCl

  • Molecular Weight 196.68 (free base basis)

  •  EC Number 265-718-0

  •  MDL number MFCD00039032

  •  PubChem Substance ID 24847652

  •  NACRES NA.22

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Properties

Related Categories Agonists, Building Blocks, C10, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   99%
mp   210-214 °C (dec.) (lit.)
solubility   methanol: soluble
SMILES string   Cl.Clc1cccc(c1)N2CCNCC2
InChI   1S/C10H13ClN2.ClH/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13;/h1-3,8,12H,4-7H2;1H
InChI key   MHXPYWFZULXYHT-UHFFFAOYSA-N
Gene Information   rat ... Htr1a(24473)

Description

General description

1-(3-Chlorophenyl)piperazine hydrochloride is sold as Ecstasy mimic tablets and is the major metabolite of the antidepressant medications trazodone and nefazodone.

Application

1-(3-Chlorophenyl)piperazine hydrochloride (CPP) has been used in determination of designer piperazines in urine specimens using GC-MS and LC-ESI-MS. CPP has been used to investigate the in vitro efficacy of newly synthesized compounds such as fluoroquinolones (norfloxacine and lomefloxacine) against Philasterides dicentrarchi .

Packaging

5, 25 g in glass bottle

Biochem/physiol Actions

1-(3-Chlorophenyl)piperazine induces hypophagia in food-deprived and freely feeding rats. CPP has affinity for 11 neurotransmitter receptor binding sites in human brain membranes.

5-HT2c serotonin receptor agonist; metabolite of trazodone.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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