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125571 Sigma-Aldrich

5-Chloro-2-mercaptobenzothiazole

technical grade, ≥90%

Synonym: 5-Chloro-2-benzothiazolethiol, CMBT

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Properties

Related Categories Building Blocks, C3 to C7, Chemical Synthesis, Glycan Labeling and Analysis, Glycobiology,
Quality Level   200
grade   technical grade
assay   ≥90%
mp   198-200 °C (lit.)
SMILES string   Sc1nc2cc(Cl)ccc2s1
InChI   1S/C7H4ClNS2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
InChI key   NKYDKCVZNMNZCM-UHFFFAOYSA-N

Description

General description

5-Chloro-2-mercaptobenzothiazole(CMBZT) reacts with iodine in a molar ratio of 1:1 to form charge-transfer complex (CMBZT)I2.

Application

5-Chloro-2-mercaptobenzothiazole (CMBZT) has been used in the analysis of lipopolysaccharide by negative-ion matrix-assisted laser desorption ionization-time of flight mass spectrometry. It has been used in the synthesis of the new mixed ligand silver(I) chloride complex with the heterocyclic thioamide CMBZT and tri(p-tolyl)phosphine. Found to be more sensitive than DHB for analysis of high mannose N-linked glycans. Used in analysis of peptidoglycan muropeptides.

Packaging

5, 10 g in glass bottle

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
DL6490000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Mass Spectrometry of Glycans

The development of modern mass spectrometry (MS) equipment with high resolution and mass accuracy has led to its use in analyzing glycans for both profiling and structural studies. Unlike the HPLC me...
Glycobiology Analysis Manual, 2nd Edition
Keywords: Catalysis, Centrifugation, High performance liquid chromatography, Mass spectrometry, Phase transitions, Proteomics, Reductions, Sample preparations, Sequencing

Methods and matrices for mass spectrometry of glycans

Glycosylation is known to have profound influence on various physiochemical, cellular and biological functions of proteins. Alterations in this modification are known to affect the immune system and ...
BioFiles v5 n1
Keywords: Addition reactions, Cancer, Capillary electrophoresis, Chromatography, Derivatizations, Digestions, Diseases, Electrophoresis, Eliminations, Fermentation, Filtration, Gas chromatography, Glycosylations, High performance liquid chromatography, Ion Exchange, Liquid chromatography mass spectrometry, Mass spectrometry, PAGE, Phase transitions, Proteomics, Purification, Sequencing

Peer-Reviewed Papers
15

References

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