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128287 Aldrich

N-Ethylmaleimide

98%

Synonym: NEM

  • CAS Number 128-53-0

  • Empirical Formula (Hill Notation) C6H7NO2

  • Molecular Weight 125.13

  •  Beilstein Registry Number 112448

  •  EC Number 204-892-4

  •  MDL number MFCD00005509

  •  PubChem Substance ID 24847840

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Properties

InChI Key   HDFGOPSGAURCEO-UHFFFAOYSA-N
assay   98%
bp   210 °C(lit.)
mp   43-46 °C(lit.)
Gene Information   human ... SLC6A3(6531), SLC6A4(6532)

Description

Application

Reagent for the covalent modification of cysteine residues in proteins.

Thiol reagent.

Biochem/physiol Actions

Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.

Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2928 8(6.1) / PGII
WGK Germany 
3
RTECS 
UX9625000
Flash Point(F) 
163.4 °F
Flash Point(C) 
73 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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Description

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E3876 N-Ethylmaleimide, crystalline, ≥98% (HPLC)

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