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  • 130672 - N-Hydroxysuccinimide

130672 Aldrich



Synonym: 1-Hydroxy-2,5-pyrrolidinedione, HOSu, NHS



Related Categories Active Esters/Additives, Chemical Reagents, Chemical Synthesis, Coupling, Development Quantities for Research,
assay   98%
mp   95-98 °C(lit.)


Frequently Asked Questions

Frequently Asked Questions are available for this Product.


Additive used in the carbodiimide method for improved amidations and peptide couplings.

Used to activate a carboxyl group for amide bond formation.


1 kg in poly bottle

5 kg in poly drum

5, 25, 100, 250 g in poly bottle

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Laboratory Gloves
Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
What is the solution stability of Product 130672, N-Hydroxysuccinimide?
Sigma-Aldrich does not evaluate 130672 for solution stability. Therefore, it is advisable to prepare a solution fresh for each use. Please note, the product is moisture sensitive.
What is the purity of Product 130672, N-Hydroxysuccinimide?
The purity is lot specific and will be stated on the Specification Sheet. See: http://www.sigmaaldrich.com/catalog/search/SpecificationSheetPage/ALDRICH/130672
Does N-Hydroxysuccinimide go by any other names?
Yes, N-Hydroxysuccinimide is also referred to by the acronym NHS and is also referred to by the synonyms 1-Hydroxy-2,5-pyrrolidinedione and HOSu.
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
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Protocols & Articles


Desalting of Immunoglobulins (IgG, Human) on HiTrap® Desalting Cartridge

From our library of Articles, Sigma-Aldrich presents Desalting of Immunoglobulins (IgG, Human) on HiTrap® Desalting Cartridge
Keywords: Chromatography, High performance liquid chromatography

Molecular Monolayers on Silicon Surfaces

Controlled formation of organic molecular monolayers on silicon surfaces offers the promise of enhancing the functionality of existing and emerging silicon based materials and devices. The synthetic ...
Gregory P. Lopinski, Daniel D.M. Wayner
Material Matters 2008, 3.2, 38.
Keywords: Adsorption, Applications, Buffers, Degradations, Diffusion, Electronics, Events, Gas chromatography, Grignard Reaction, Hydrosilylations, Immobilization, Infrared spectroscopy, Methods, Microelectronics, Microscopy, Nanomaterials, Nucleic acid hybridization, Oxidations, Reductions, Semiconductor, Solvents, Sonication, Spectra, Surface Science, Transduction

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