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138630 Sigma-Aldrich

1-Chloro-2,4-dinitrobenzene

97%

Synonym: 2,4-Dinitrochlorobenzene, CDNB, DNCB

  • CAS Number 97-00-7

  • Linear Formula ClC6H3(NO2)2

  • Molecular Weight 202.55

  •  Beilstein/REAXYS Number 613161

  •  EC Number 202-551-4

  •  MDL number MFCD00007075

  •  PubChem Substance ID 24848362

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, Chemical Synthesis, Nitro Compounds, Nitrogen Compounds - Organic Building Blocks, Organic Building Blocks More...
Quality Level   100
assay   97%
expl. lim.   22 %
bp   315 °C (lit.)
mp   48-50 °C (lit.)
solubility   alcohol: soluble (hot)
  alcohol: very slightly soluble (cold)
  benzene: soluble
  carbon disulfide: soluble
  diethyl ether: soluble
  water: insoluble
SMILES string   [O-][N+](=O)c1ccc(Cl)c(c1)[N+]([O-])=O
InChI   1S/C6H3ClN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H
InChI key   VYZAHLCBVHPDDF-UHFFFAOYSA-N

Description

Application

1-Chloro-2,4-dinitrobenzene was used in determination of relative amounts of individual glutathione S-transferases subunits in human tissues by reverse-phase HPLC. It was used as contact sensitizer to study the antibacterial peptides hBD-2, -3 and -4 and LL-37 induced IL-18 protein release in human keratinocytes.

Packaging

5, 100, 500 g in glass bottle

Biochem/physiol Actions

2,4-dinitrochlorobenzene induces atopic dermatitis in BALB/c mice model.

Preparation Note

The product is dissolved in ethanol when used as glutathione S-transferase substrate and then added to a buffer to form a final concentration of 1mM in phosphate buffer (8 mL of 0.2 M KH2PO4 and 28 mL of 0.1 M Na2HPO4 per 100 mL of solution, adjusted to pH 6.5) and 4% (v/v) ethanol.

Safety & Documentation

Safety Information

Signal word 
Danger
RIDADR 
UN 3441 6.1 / PGII
WGK Germany 
WGK 2
RTECS 
CZ0525000
Flash Point(F) 
381.2 °F - closed cup
Flash Point(C) 
194 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Meet Synthia - Retrosynthesis Sofware
Protocols & Articles
Peer-Reviewed Papers
15

References

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