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139742 Sigma-Aldrich

Phenyl isothiocyanate

reagent grade, 98%

Synonym: PITC

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Properties

grade   reagent grade
InChI Key   QKFJKGMPGYROCL-UHFFFAOYSA-N
assay   98%
refractive index   n20/D 1.6515 (lit.)
bp   218 °C(lit.)
mp   −21 °C (lit.)
solubility   water: insoluble
density   1.132 g/mL at 20 °C (lit.)

Description

General description

Phenyl isothiocyanate is an aromatic isothiocyanate. It participates in dehydration reactions of alcohols. It is widely used for synthesis of various biologically important heterocyclic compounds.

Application

Phenyl isothiocyanate may be employed as a derivatization reagent for high-performance liquid chromatographic (HPLC) analysis of various amphetamine derivatives in body fluids for forensic purposes.
Phenyl isothiocyanate (PIT) modified with polyethylene glycol (PEG), can be used as a reagent for PEGylation of protein using human serum albumin as a model protein.

Derivatizing reagent for primary and secondary amines. Used in sequencing peptides by Edman degradation and in amino acid analyses by HPLC.

Packaging

100, 500 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2927 8(6.1) / PGII
WGK Germany 
3
RTECS 
NX9275000
Flash Point(F) 
190.4 °F
Flash Point(C) 
88 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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