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143502 Sigma-Aldrich

Trimethylacetic anhydride

99%

Synonym: 2,2-Dimethylpropionic anhydride, Pivalic anhydride

  • CAS Number 1538-75-6

  • Linear Formula [(CH3)3CCO]2O

  • Molecular Weight 186.25

  •  Beilstein/REAXYS Number 386552

  •  EC Number 216-263-1

  •  MDL number MFCD00008842

  •  PubChem Substance ID 24848589

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, Carbonyl Compounds, Carboxylic Acid Anhydrides, Chemical Synthesis, Organic Building Blocks More...
Quality Level   200
assay   99%
refractive index   n20/D 1.409 (lit.)
bp   193 °C (lit.)
density   0.918 g/mL at 25 °C (lit.)
SMILES string   CC(C)(C)C(=O)OC(=O)C(C)(C)C
InChI   1S/C10H18O3/c1-9(2,3)7(11)13-8(12)10(4,5)6/h1-6H3
InChI key   PGZVFRAEAAXREB-UHFFFAOYSA-N

Description

Application

Acylation and esterification reagent for anilines and phenols, respectively.

Trimethylacetic anhydride was used:
• in solid-phase oligonucleotide synthesis
• in kinetic resolution of racemic 2-hydroxy-γ-butyrolactones with diphenylacetic acid
• as acylation and esterification reagent for anilines
• as acylation and esterification reagent for phenols

Packaging

25, 100 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2920 3(8) / PGII
WGK Germany 
WGK 3
Flash Point(F) 
134.6 °F - closed cup
Flash Point(C) 
57 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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