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145505 Sigma-Aldrich

α-Cyano-4-hydroxycinnamic acid

97%

Synonym: α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA, alpha-Cyano-4-hydroxycinnamic acid

  • CAS Number 28166-41-8

  • Linear Formula HOC6H4CH=C(CN)CO2H

  • Molecular Weight 189.17

  •  Beilstein Registry Number 3271427

  •  EC Number 248-879-1

  •  MDL number MFCD00004204

  •  PubChem Substance ID 24848731

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Properties

Related Categories Building Blocks, C10, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis,
InChI Key   AFVLVVWMAFSXCK-VMPITWQZSA-N
assay   97%
mp   245-250 °C (lit.)
solubility   methanol: soluble 50 mg/mL, clear to slightly hazy, light yellow to yellow
storage temp.   2-8°C

Description

Packaging

5, 25 g in glass bottle

Application

α-Cyano-4-hydroxycinnamic acid(CHC) was used as a matrix for peptides and nucleotides in mass spectroscopic analysis. It was used in encapsulation of CHC into NaY zeolite. It was used as matrix to investigate the activity of the paclitaxel derivatives using several well-established in vitro angiogenesis assays.

General description

α-Cyano-4-hydroxycinnamic acid is the commonly used matrix for analyzing peptides by matrix-assisted laser desorption/ionization mass spectrometry. It inhibits the monophenolase activity and diphenolase activity of mushroom tyrosinase.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What can be used for solublization ofα-Cyano-4-hydroxycinnamic acid?
α-Cyano-4-hydroxycinnamic acid (α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA) is soluble in methanol (up to 50 mg/ml). It is also soluble at 10 mg/ml using 50% acetonitrile in 0.05% TFA for MALDI-MS. The acetonitrile concentration can be adjusted for individual preferences.For biological applications, it has been solubilized at 100 mM in DMSO or 50 mM in ethanol.
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