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145998 Sigma-Aldrich

2-Quinoxaloyl chloride

Synonym: 2-Quinoxalinecarbonyl chloride

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Properties

Related Categories Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Quinoxalines
mp   113-115 °C (lit.)
storage temp.   2-8°C
SMILES string   ClC(=O)c1cnc2ccccc2n1
InChI   1S/C9H5ClN2O/c10-9(13)8-5-11-6-3-1-2-4-7(6)12-8/h1-5H
InChI key   SOPDQKNXOCUBSR-UHFFFAOYSA-N

Description

General description

2-Quinoxaloyl chloride reacts with chiral α-hydroxy carboxylic acids to yield UV and fluorescent derivatives.

Application

2-Quinoxaloyl chloride was used in the synthesis of novel DNA interactive quinoxaline-carbohydrate hybrids possessing disaccharides as the carbohydrate moieties.

Reactant involved in the synthesis of a variety of inhibitors including:
• Gelatinase inhibitors for cancer treatments
• mGluR5 non-competitve antagonists
• Heterocyclic analogs used as SIRT1 activators
• 3rd Generation multidrug resistance modulators

Reactant involved in preparation of PET ligants for breast cancer resistance protein imaging

Packaging

1 g in glass bottle

250 mg in amber glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3261 8 / PGII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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