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156671 Sigma-Aldrich

Potassium tert-butoxide

Green Alternative

reagent grade, ≥98%

Synonym: Potassium tert-butylate, Potassium t-butoxide



Related Categories 12 Principles Aligned Products, Acids & Bases, Bases, Chemical Reagents, Chemical Synthesis,
grade   reagent grade
vapor pressure   1 mmHg ( 220 °C)
assay   ≥98%
form   solid
greener alternative product characteristics   Catalysis
Learn more about the Principles of Green Chemistry.
mp   256-258 °C (dec.) (lit.)


General description

Sigma Life Science is committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for energy efficiency. Find details here.


Used for greener amidation of esters.

tert-Butoxide-Assisted Amidation of Esters under Green Conditions

Potassium tert-butoxide may be used as a base in the intramolecular cyclization of iodo arene to afford benzopyran via microwave method of synthesis.


2.5 kg in poly bottle

25 kg in steel drum

5, 25, 100, 500 g in poly bottle

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Supplemental Hazard Statements 
Reacts violently with water.
UN 3131 8(4.3) / PGI
WGK Germany 


Certificate of Analysis


Certificate of Origin

Protocols & Articles


Acids and Bases

Acids and bases have been used by chemists for centuries, and are among the most fundamental reagents employed in synthetic organic chemistry. This product line ranges from Brønsted and Lewis acids, ...
Chemfiles Volume 1 Article 3

Boronic Acids: New Coupling Partners in Room-Temperature Suzuki Reactions of Alkyl Bromides. Crystallographic Characterization of an Oxidative-Addition Adduct Generated under Remarkably Mild Conditions

Pd(PhCN)2Cl2/P(t-Bu)2 serves as an efficient and a versatile catalyst for room-temperature Sonogashira reactions of aryl bromides.
Keywords: Chromatography, Flash chromatography, Precipitation

Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides

A series of palladacyclic precatalysts that incorporate electron-rich di-tert-butylphosphino biaryl ligands is reported. These precatalysts are easily prepared, and their use provides a general means...
Keywords: Amidations, Catalysis, Chromatography, Coupling reactions, Cross couplings, Flash chromatography, Ligands, Thin layer chromatography


Amide Bond & Catalytic Amide Bond Formation: Greener Methods

The amide bond is one of the most important linkages in organic chemistry and constitutes the key functional group in peptides, polymers, and many natural products and pharmaceuticals.  Amides are us...
Keywords: Amidations, Beckmann Rearrangement, Catalysis, Chromatography, Column chromatography, Ligands, Peptide synthesis, Pharmaceutical, Rearrangements, Schmidt Reaction, transformation

Boxed reaction: Buchwald-Hartwig in Lipshutz Surfactant

Please consult the Safety Data Sheet for information regarding hazards and safe handling practices.
Keywords: Aminations, Buchwald-Hartwig amination, Chromatography, Flash chromatography, Ligands

Buchwald Hartwig Amination Kit

Please consult the Safety Data Sheet for information regarding hazards and safe handling practices.
Keywords: Chromatography, Column chromatography, Gas chromatography, High performance liquid chromatography, Ligands, Thin layer chromatography

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The molarity calculator tool provides lab-ready directions describing how to prepare an acid or base solution of specified Molarity (M) or Normality (N) from a concentrated acid or base solution. To ...

Peer-Reviewed Papers


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