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156671 Aldrich

Potassium tert-butoxide Green Alternative

reagent grade, ≥98%

Synonym: Potassium tert-butylate, Potassium t-butoxide

  • CAS Number 865-47-4

  • Linear Formula (CH3)3COK

  • Molecular Weight 112.21

  •  Beilstein Registry Number 3556712

  •  EC Number 212-740-3

  •  MDL number MFCD00012162

  •  PubChem Substance ID 24849626

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Properties

Related Categories 12 Principles Aligned Products, Acids & Bases, Bases, Chemical Reagents, Chemical Synthesis,
grade   reagent grade
vapor pressure   1 mmHg ( 220 °C)
InChI Key   LPNYRYFBWFDTMA-UHFFFAOYSA-N
assay   ≥98%
form   solid
greener alternative product characteristics   Catalysis
Learn more about the Principles of Green Chemistry.
mp   256-258 °C (dec.) (lit.)

Description

Packaging

2.5 kg in poly bottle

25 kg in steel drum

5, 25, 100, 500 g in poly bottle

Application

Used for greener amidation of esters.

tert-Butoxide-Assisted Amidation of Esters under Green Conditions

Potassium tert-butoxide may be used as a base in the intramolecular cyclization of iodo arene to afford benzopyran via microwave method of synthesis.

General description

Sigma Life Science is committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for energy efficiency. Find details here.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Supplemental Hazard Statements 
Reacts violently with water.
RIDADR 
UN 3131 8(4.3) / PGI
WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin


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Protocols & Articles

Articles

Acids and Bases

Acids and bases have been used by chemists for centuries, and are among the most fundamental reagents employed in synthetic organic chemistry. This Aldrich product line ranges from Brønsted and Lewis...
Chemfiles Volume 1 Article 3

Boronic Acids: New Coupling Partners in Room-Temperature Suzuki Reactions of Alkyl Bromides. Crystallographic Characterization of an Oxidative-Addition Adduct Generated under Remarkably Mild Conditions

Pd(PhCN)2Cl2/P(t-Bu)2 serves as an efficient and a versatile catalyst for room-temperature Sonogashira reactions of aryl bromides.
Keywords: Chromatography, Flash chromatography, Precipitation

Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides

A series of palladacyclic precatalysts that incorporate electron-rich di-tert-butylphosphino biaryl ligands is reported. These precatalysts are easily prepared, and their use provides a general means...
Keywords: Amidations, Catalysis, Chromatography, Coupling reactions, Cross couplings, Flash chromatography, Ligands, Thin layer chromatography

Protocols

Boxed reaction: Buchwald-Hartwig in Lipshutz Surfactant

Please consult the Safety Data Sheet for information regarding hazards and safe handling practices.
Keywords: Aminations, Buchwald-Hartwig amination, Chromatography, Flash chromatography, Ligands

Buchwald Hartwig Amination Kit

Please consult the Safety Data Sheet for information regarding hazards and safe handling practices.
Keywords: Chromatography, Column chromatography, Gas chromatography, High performance liquid chromatography, Ligands, Thin layer chromatography

Catalytic Amide Bond Formation: Greener Methods

The amide bond is one of the most important linkages in organic chemistry and constitutes the key functional group in peptides, polymers, and many natural products and pharmaceuticals.  Amides are us...
Keywords: Amidations, Beckmann Rearrangement, Catalysis, Chromatography, Column chromatography, Ligands, Peptide synthesis, Pharmaceutical, Rearrangements, Schmidt Reaction, transformation

Related Content

Molarity Calculator & Normality Calculator for Acids & Bases

The molarity calculator tool provides lab-ready directions describing how to prepare an acid or base solution of specified Molarity (M) or Normality (N) from a concentrated acid or base solution. To ...

Peer-Reviewed Papers
15

References

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