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158194 Sigma-Aldrich

2,2′-Dithiobis(5-nitropyridine)

96%

Synonym: Bis(5-nitro-2-pyridyl) disulfide, DTNP

  • CAS Number 2127-10-8

  • Empirical Formula (Hill Notation) C10H6N4O4S2

  • Molecular Weight 310.31

  •  Beilstein/REAXYS Number 305413

  •  EC Number 218-344-7

  •  MDL number MFCD00006453

  •  PubChem Substance ID 24849723

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, C10, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines More...
assay   96%
mp   155-157 °C (lit.)
SMILES string   [O-][N+](=O)c1ccc(SSc2ccc(cn2)[N+]([O-])=O)nc1
InChI   1S/C10H6N4O4S2/c15-13(16)7-1-3-9(11-5-7)19-20-10-4-2-8(6-12-10)14(17)18/h1-6H
InChI key   ROUFCTKIILEETD-UHFFFAOYSA-N

Description

General description

2,2′-Dithiobis(5-nitropyridine) is an aromatic disulphide.

Application

2,2′-Dithiobis(5-nitropyridine) was employed:
• as cysteine-activating reagent to study the NMR of G protein-coupled receptors
• in the deprotection assays for protected selenocysteine-containing peptides
• for deprotecting p-methoxybenzyl groups and acetamidomethyl groups from the side-chains of cysteine and selenocysteine
• to remove the p-methoxybenzyl protecting group from cysteine and selenocysteine side-chains

Packaging

1, 10 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
UT2964000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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