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161543 Sigma-Aldrich

5-(4-Hydroxyphenyl)-5-phenylhydantoin

98%

Synonym: 4-Hydroxydiphenylhydantoin, p-Hydroxyphenytoin, NSC 156081

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Properties

Related Categories Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Imidazolines/Imidazolidines
InChI Key   XEEDURHPFVXALT-UHFFFAOYSA-N
assay   98%
mp   >300 °C (lit.)
solubility   soluble 50 mg/mL, clear, colorless to faintly yellow (DMF:MeOH(2:1))

Description

General description

5-(4-Hydroxyphenyl)-5-phenylhydantoin is the major metabolite of phenytoin.

Application

5-(4-Hydroxyphenyl)-5-phenylhydantoin was used in enantiomeric separation of chiral pharmaceuticals using a teicoplanin chiral stationary phase by aqueous and non-aqueous packed capillary electrochromatography. It was used as internal standard in determination of phenylbutazone and its metabolite oxyphenbutazone in human plasma by GLC.

Reactant for activation of hydroxylated metabolites of carbamazepine and phenytoin

Used in studies investigating
Transport across the human placenta barrier
Effects on cellular glucose transport

Packaging

1 g in glass bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 161543.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
MU2485000

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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