• USA Home
  • 163872 - Ethyl malonyl chloride

EMAIL THIS PAGE TO A FRIEND
163872 Sigma-Aldrich

Ethyl malonyl chloride

technical grade

Synonym: Ethyl (chloroformyl)acetate, Ethyl 3-chloro-3-oxopropionate

  • CAS Number 36239-09-5

  • Linear Formula CH3CH2OCOCH2COCl

  • Molecular Weight 150.56

  •  Beilstein/REAXYS Number 636215

  •  EC Number 252-934-5

  •  MDL number MFCD00000736

  •  PubChem Substance ID 24850040

  •  NACRES NA.22

Purchase

Properties

Related Categories Acid Halides, Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks More...
Quality Level   200
grade   technical grade
refractive index   n20/D 1.429 (lit.)
bp   79-80 °C/25 mmHg (lit.)
density   1.176 g/mL at 25 °C (lit.)
storage temp.   2-8°C
SMILES string   CCOC(=O)CC(Cl)=O
InChI   1S/C5H7ClO3/c1-2-9-5(8)3-4(6)7/h2-3H2,1H3
InChI key   KWFADUNOPOSMIJ-UHFFFAOYSA-N

Description

General description

Ethyl malonyl chloride is a versatile acylating agent for propargyl alcohols, hydrazines and amines.

Application

Ethyl malonyl chloride was used in the synthesis of:
• liquid-crystalline methanofullerodendrimers
• 3,5-disubstituted 1,2,4-oxadiazole derivatives, which are potential peptidomimetic building blocks
• 3-pyrrolin-2-ones via amidation with propargylamines and subsequent base catalyzed 5-exo-dig cyclization

Packaging

5, 25 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
Supplemental Hazard Statements 
EUH014
RIDADR 
UN 3265 8 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
147.2 °F - closed cup
Flash Point(C) 
64 °C - closed cup
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

08168 Timestrip Plus 8 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?