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166979 Sigma-Aldrich

Dimethyl 3-hydroxyglutarate

98%

  • CAS Number 7250-55-7

  • Linear Formula CH3OCOCH2CH(OH)CH2COOCH3

  • Molecular Weight 176.17

  •  Beilstein/REAXYS Number 1776666

  •  MDL number MFCD00042841

  •  PubChem Substance ID 24850190

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, C6 to C7, Carbonyl Compounds, Chemical Synthesis, Esters,
Quality Level   100
assay   98%
refractive index   n20/D 1.442 (lit.)
bp   139-140 °C/8 mmHg (lit.)
density   1.192 g/mL at 25 °C (lit.)
SMILES string   COC(=O)CC(O)CC(=O)OC
InChI   1S/C7H12O5/c1-11-6(9)3-5(8)4-7(10)12-2/h5,8H,3-4H2,1-2H3
InChI key   CUPGMRSSZADEIW-UHFFFAOYSA-N

Description

General description

Enantioselective hydrolysis and ammonolysis of dimethyl-3-hydroxyglutarate has been studied using immobilized lipase B isolated from Candida antarctica.

Application

Dimethyl 3-hydroxyglutarate was used in the synthesis of two chiral fragments representing C1-11 and C12-25 of the polyene macrolide pimaricin.

Packaging

5 g in glass bottle

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
235.4 °F - closed cup
Flash Point(C) 
113 °C - closed cup
Protocols & Articles
Peer-Reviewed Papers
15

References

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