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185892 Sigma-Aldrich

Ethyl chloroformate

97%

Synonym: Chloroformic acid ethyl ester

  • CAS Number 541-41-3

  • Linear Formula ClCOOC2H5

  • Molecular Weight 108.52

  •  Beilstein/REAXYS Number 385653

  •  EC Number 208-778-5

  •  MDL number MFCD00000644

  •  PubChem Substance ID 24851187

  •  NACRES NA.22

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Properties

Related Categories Acid Halides, Building Blocks, Carbonyl Compounds, Chemical Reagents, Chemical Synthesis,
Quality Level   200
vapor density   3.74 (vs air)
vapor pressure   3.42 psi ( 20 °C)
assay   97%
autoignition temp.   842 °F
refractive index   n20/D 1.395 (lit.)
bp   93 °C (lit.)
mp   −81 °C (lit.)
solubility   alcohol: miscible
  benzene: miscible
  chloroform: miscible
  diethyl ether: miscible
  water: insoluble
density   1.135 g/mL at 25 °C (lit.)
SMILES string   CCOC(Cl)=O
InChI   1S/C3H5ClO2/c1-2-6-3(4)5/h2H2,1H3
InChI key   RIFGWPKJUGCATF-UHFFFAOYSA-N

Description

Application

• Ethyl chloroformate was used in the synthesis of nitrile oxides.
• It was used as derivatization reagent to investigate stereochemical conversion of chiral non-steroidal anti-inflammatory drugs during derivatization reaction.
• It was used to develop flexible template strategy for the generation of nanometer-scale templates via dip-pen nanolithography.
• It was used as derivatization reagent in an enantiomeric analysis of amino acids by two-dimensional gas chromatography.
• It was also used with ammonia and cyanuric chloride to convert carboxylic acids to nitriles.

Packaging

100, 500 g in Sure/Seal™

2 kg in poly bottle

5 g in glass bottle

Derivatization reagent employed in an enantiomeric analysis of amino acids by two-dimensional gas chromatography. Also used with ammonia and cyanuric chloride to convert carboxylic acids to nitriles.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN1182 - class 6.1 - PG 1 - Ethyl chloroformate
WGK Germany 
WGK 1
Flash Point(F) 
50.0 °F - closed cup
Flash Point(C) 
10 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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