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188425 Sigma-Aldrich

3-Methylindene-2-carboxylic acid

98%

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Properties

Related Categories Building Blocks, C11 to C12, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis,
Quality Level   100
assay   98%
mp   201-203 °C (lit.)
SMILES string   CC1=C(Cc2ccccc12)C(O)=O
InChI   1S/C11H10O2/c1-7-9-5-3-2-4-8(9)6-10(7)11(12)13/h2-5H,6H2,1H3,(H,12,13)
InChI key   RONBYWGSEXDEKC-UHFFFAOYSA-N

Description

General description

3-Methylindene-2-carboxylic acid undergoes asymmetric hydrogenation over Pd/Al2O3 in the presence of cinchonidine as a chiral modifier.

Application

3-Methylindene-2-carboxylic acid was used in the synthesis of:
• LKS01-B650, an imaging probe that selectively binds the catalytically active LMP7 subunit of immunoproteasome in living cells
• 1-methylindane-2-carboxylic acid via reduction with sodium amalgam

Packaging

2.5 g in glass bottle

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

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Protocols & Articles
Peer-Reviewed Papers
15

References

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