• USA Home
  • 190500 - tert-Butyldimethylsilyl chloride

190500 Sigma-Aldrich

tert-Butyldimethylsilyl chloride

reagent grade, 97%

Synonym: tert-Butyl(chloro)dimethylsilane, tert-Butyldimethylchlorosilane, TBDMSCl

  • CAS Number 18162-48-6

  • Linear Formula (CH3)3CSi(CH3)2Cl

  • Molecular Weight 150.72

  •  Beilstein/REAXYS Number 505999

  •  EC Number 242-042-4

  •  MDL number MFCD00000501

  •  PubChem Substance ID 24851442

  •  NACRES NA.22



Related Categories Chemical Synthesis, Protecting and Derivatizing Reagents, Protection and Derivatization, Silicon-Based, Synthetic Reagents More...
grade   reagent grade
assay   97%
bp   125 °C (lit.)
mp   86-89 °C (lit.)
SMILES string   CC(C)(C)[Si](C)(C)Cl
InChI   1S/C6H15ClSi/c1-6(2,3)8(4,5)7/h1-5H3



Versatile protecting reagent for amines, amides, and especially alcohols, among others. Can be selectively removed in the presence of a t-BuPh2Si-protected alcohol.
Used in a preparatrion of isoxazoline N-oxides from α-bromonitroalkanes.


1 kg in glass bottle

5, 25, 100, 500 g in glass bottle

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
UN 2925 8(4.1) / PGII
WGK Germany 
Flash Point(F) 
71.6 °F
Flash Point(C) 
22 °C

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
What is the solubility of Product 190500, tert-Butyldimethylsilyl chloride?
It is soluble in organic solvents such as chloroform, toluene, tetrahydrofuran (THF), and dichloromethane. It reacts with water.
What types of compounds can Product 190500, tert-Butyldimethylsilyl chloride, be used as a protecting reagent for?
This product is a versatile protecting reagent for amines, amides, and especially alcohols.
How can Product 190500, tert-Butyldimethylsilyl chloride, be used as a silylating reagent?
When this compound was initially used as a silylation agent, it was found by E. J. Corey (J. Am. Chem. Soc. 1972, 94, 6192) to react very slowly and to give unsatisfactory yields with alcohols. Even forcing silylation techniques (excess silyl chloride, dry pyridine, elevated temperatures) were not successful. The use of 2.5 eq. imidazole as catalyst with 1.2 eq. of tert-butyldimethylsilyl chloride and dimethylformamide as solvent proved to be effective, and resulted in the mild conversion of various alcohols to tert-butyldimethylsilyl ethers in high yield.
Is Product 190500, tert-Butyldimethylsilyl chloride, packaged under inert atmosphere?
Since this product is readily hydrolyzed, we do package this product under nitrogen atmosphere.
How else canProduct 190500, tert-Butyldimethylsilyl chloride, silylating reagent be used?
This silylating agent can be used to determine conformation of cholesterol derivatives.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
Show more questions
Protocols & Articles


Activating Reagents and Protecting Groups

The use of activating agents and protecting groups in organic synthesis is necessary to prevent unwanted side reactions from occurring when using other common reagents such as oxidizing or reducing a...
Chemfiles Volume 1 Article 3
Keywords: Organic synthesis

Peer-Reviewed Papers


Related Products

related product

Product #


Add to Cart

901741 Bis(triphenyl-λ5-phosphanylidene)ammonium hydrogendifluoride
394882 N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide, >97%
375934 N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane, ≥95%
473464 tert-Butylchlorodimethylsilane solution, 50 wt. % in toluene
384429 tert-Butyldimethylsilyl chloride solution, 1.0 M in methylene chloride
372951 tert-Butyldimethylsilyl chloride solution, 1.0 M in THF
226149 tert-Butyldimethylsilyl trifluoromethanesulfonate, reagent grade, 98%
250236 1-(tert-Butyldimethylsilyl)imidazole, ≥95%
06735 tert-Butyldimethylsilyl chloride, for GC derivatization, LiChropur, ≥99.0% (GC)
56563 tert-Butyldimethylsilyl trifluoromethanesulfonate, for GC derivatization, LiChropur, ≥98.0% (T)
77626 N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide, for GC derivatization, LiChropur, ≥99.0% (GC)
00942 N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane, for GC derivatization, LiChropur, ≥95.0% (GC)
89539 N,O-Bis(tert-butyldimethylsilyl)trifluoroacetamide, for GC derivatization
44795 N,O-Bis(tert-butyldimethylsilyl)acetamide, for GC derivatization, LiChropur, ≥98.0% (GC)

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?