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195359 Sigma-Aldrich

4-Fluorobenzotrifluoride

98%

Synonym: α,α,α,4-Tetrafluorotoluene

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Properties

Related Categories Aryl, Aryl Fluorinated Building Blocks, Building Blocks, C7, Chemical Synthesis,
Quality Level   100
assay   98%
refractive index   n20/D 1.401 (lit.)
bp   102-105 °C (lit.)
mp   −42-−41.7 °C (lit.)
density   1.293 g/mL at 25 °C (lit.)
SMILES string   Fc1ccc(cc1)C(F)(F)F
InChI   1S/C7H4F4/c8-6-3-1-5(2-4-6)7(9,10)11/h1-4H
InChI key   UNNNAIWPDLRVRN-UHFFFAOYSA-N

Description

Application

4-Fluorobenzotrifluoride was used in the synthesis of:
• 2,2′-bis(trifluoromethylphenoxy)biphenyl via nucleophilic aromatic substitution reaction with 2,2′-biphenol
• (S)-fluoxetine, potent inhibitor of neuronal serotonin-uptake
• 1-aryloxy-2-substituted aminomethyltetrahydronaphthalene derivatives

Packaging

5, 25 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
RIDADR 
UN 1993BF 3 / PGII
WGK Germany 
WGK 3
Flash Point(F) 
51.8 °F - closed cup
Flash Point(C) 
11 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Meet Synthia - Retrosynthesis Sofware
Protocols & Articles
Peer-Reviewed Papers
15

References

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