• USA Home
  • 201170 - Phosphorus(V) oxychloride

EMAIL THIS PAGE TO A FRIEND
201170 Sigma-Aldrich

Phosphorus(V) oxychloride

ReagentPlus®, 99%

Synonym: Phosphorus(V) oxide chloride, Phosphoryl chloride

Purchase

Properties

Related Categories C-X Bond Formation (Halogen), Chemical Synthesis, Chlorination, Synthetic Reagents
Quality Level   200
vapor density   5.3 (vs air)
vapor pressure   104 mmHg ( 50 °C)
  28 mmHg ( 20 °C)
product line   ReagentPlus®
assay   99%
form   liquid
pH   1 (20 °C)
bp   105.8 °C (lit.)
mp   1.25 °C (lit.)
density   1.645 g/mL at 25 °C (lit.)
SMILES string   ClP(Cl)(Cl)=O
InChI   1S/Cl3OP/c1-5(2,3)4
InChI key   XHXFXVLFKHQFAL-UHFFFAOYSA-N

Description

Application

Phosphorus(V) oxychloride (POCl3) is a chlorinating agent that reacts with dimethylformamide (DMF) to form Vilsmeier reagent for Vilsmeier-Haack formylation reactions.
It can also be used as a reagent in the synthesis of:
•  Quinazolin-4(3H)-one derivatives from 2-aminobenzamides via in situ preparation of Vilsmeier reagent.
•  Substituted 1-arylseleno-4-halo-2-enes by treating conjugated dienes with arylselenenamides.
•  3-methylthioimidazo[1,2-a]pyridines and imidazo-fused heterocycles in the presence of DMSO.

Packaging

1 kg in glass bottle

5, 250 g in glass bottle

View returnable container options.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 1810 8
WGK Germany 
WGK 1
RTECS 
TH4897000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?