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215430 Sigma-Aldrich

α-(4-Pyridyl N-oxide)-N-tert-butylnitrone

99%

Synonym: N-tert-Butyl-α-(4-pyridyl)nitrone N′-oxide, N-(4-Pyridylmethylene)-tert-butylamine N,N′-dioxide, POBN

  • CAS Number 66893-81-0

  • Empirical Formula (Hill Notation) C10H14N2O2

  • Molecular Weight 194.23

  •  Beilstein/REAXYS Number 1453764

  •  EC Number 266-512-3

  •  MDL number MFCD00041022

  •  PubChem Substance ID 24852894

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Building Blocks, C10, Chemical Synthesis,
InChI Key   RNRMWTCECDHNQU-XYOKQWHBSA-N
assay   99%
mp   183-185 °C (lit.)
solubility   water: soluble 10 mg/mL, clear, colorless to faintly yellow

Description

Application

α-(4-Pyridyl N-oxide)-N-tert-butylnitrone was used as spin trapping agent to detect:
• the formation of hydroxyl radical adducts during decomposition of hydrogen peroxide in the presence of nickel (II) oligopeptides
• hydroxyl radicals and selenide radical anions

Spin trap reagent used to measure ethanol oxidation to 1-hydroxyethyl radical (HER) which can bind to protein. Has also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide. The formation of hydroxyl radical in chondrocytes and cartilage has been detected using POBN.

Packaging

1 g in glass bottle

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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