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216143 Sigma-Aldrich

Tetrabutylammonium fluoride solution

1.0 M in THF

Synonym: TBAF solution

  • CAS Number 429-41-4

  • Linear Formula [CH3(CH2)3]4NF

  • Molecular Weight 261.46

  •  Beilstein/REAXYS Number 3762762

  •  MDL number MFCD00011747

  •  PubChem Substance ID 24852802

  •  NACRES NA.22



Related Categories Chemical Synthesis, Deprotecting Reagents, Fluoride Sources, Protection and Derivatization, Synthetic Reagents More...
Quality Level   200
concentration   1.0 M in THF
impurities   ~5 wt. % water
density   0.903 g/mL at 25 °C
storage temp.   2-8°C
InChI   1S/C16H36N.FH/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;/h5-16H2,1-4H3;1H/q+1;/p-1



Reactant for preparation of:
• Triple monoamine reuptake inhibitors as a new generation of antidepressants
• Alcohols via hydrolysis of alkyl silyl ethers neutral pH in mixed organic-aqueous buffered solutions
• Oligoribonucleotides with phosphonate-modified linkages
• Aryl alkyl alcohols via Nozaki-Hiyama allylation catalyzed by chiral bipyridyldiol ligands and chromium trichloride
• Conjugated dienoic acid esters using Suzuki coupling reactions
• Macrocyclic o-aminobenzamide Hsp90 inhibitorwith antitumor activity
• Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors
• Anti-diabetic polyacetylenic glucosides


1 L in Sure/Seal™

5 mL in glass bottle

2.5 L in glass bottle

50, 100, 4×100, 500 mL in Sure/Seal™

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Supplemental Hazard Statements 
May form explosive peroxides.
UN 2924 8(3) / PGII
WGK Germany 
Flash Point(F) 
1.4 °F
Flash Point(C) 
-17 °C


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How should Product 216143, Tetrabutylammonium fluoride solution be stored?
This product is hygroscopic and should be stored under inert gas, such as nitrogen, and at 2-8 degC, which is in accordance with our MSDS.
What applications can 216143 Tetrabutylammonium fluoride solution, be used in?
This product can be used as a fluorinating reagent.
What causes Product 216143, Tetrabutylammonium fluoride solution, to turn purple?
Our specifications for this product indicate the material should be colorless to yellow in color. Contact with ketones will immediate discoloration sometimes appearing purple in color.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
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Protocols & Articles


Introduction of Terminal Azide and Alkyne Functionalities in Polymers

“Click” chemistry, and the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) in particular, is a powerful new synthetic tool in polymer chemistry and material science. Success of the CuAAC in th...
Dr. Joost A. Opsteen
Material Matters 2008, 3.3, 66.
Keywords: Building blocks, Catalysis, Cycloadditions, Esterifications, Materials Science, Nucleophilic substitutions, Polymer science, Polymerization reactions, Radical polymerization, Substitutions, transformation

Peer-Reviewed Papers


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