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  • 216666 - Tetrakis(triphenylphosphine)palladium(0)

216666 Sigma-Aldrich



Synonym: Palladium-tetrakis(triphenylphosphine), Pd(PPh3)4

  • CAS Number 14221-01-3

  • Linear Formula Pd[(C6H5)3P]4

  • Molecular Weight 1155.56

  •  Beilstein/REAXYS Number 6704828

  •  EC Number 238-086-9

  •  MDL number MFCD00010012

  •  PubChem Substance ID 24852971

  •  NACRES NA.22



Related Categories Catalysis and Inorganic Chemistry, Chemical Synthesis, Favipiravir, Homogeneous Pd Catalysts, Palladium Catalysts,
assay   99%
reaction suitability   reaction type: Heck Reaction
  reaction type: Hiyama Coupling
  reaction type: Negishi Coupling
  reaction type: Sonogashira Coupling
  reaction type: Stille Coupling
  reaction type: Suzuki-Miyaura Coupling
  reagent type: catalyst
reaction type: Buchwald-Hartwig Cross Coupling Reaction
SMILES string   [Pd].c1ccc(cc1)P(c2ccccc2)c3ccccc3.c4ccc(cc4)P(c5ccccc5)c6ccccc6.c7ccc(cc7)P(c8ccccc8)c9ccccc9.c%10ccc(cc%10)P(c%11ccccc%11)c%12ccccc%12
InChI   1S/4C18H15P.Pd/c4*1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18;/h4*1-15H;



• Catalyst for Negishi coupling (eq. 1), Suzuki coupling (eq. 2), Stille coupling (eq. 3), and Sonogashira coupling reaction (eq. 4)
• Catalyst for Buchwald-Hartwig amination reaction (eq. 5)
• Catalyst for the carbonylation of vinyl iodides (eq. 6)
• Catalyst for reduction reaction of aryl bromides (eq. 7)
• Catalyst for carbon-tin bond formation (eq. 8)
Triphenyl Phosphine Catalyst

Application Guide for Palladium Catalyzed Cross-Coupling Reactions


1, 5, 25, 4×25 g in glass bottle

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
The color of Product 216666, Pd tetrakis(triphenylphosphine)Cl was a yellow or gold color, but now my material has turned a tan, brown, or green color. Is it still good to use?
A change in color of the material indicates oxidation and it will no longer be active as a catalyst.
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What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Protocols & Articles


Catalysts and Metals

We supply a large variety of catalysts and metals that are of increasing importance to the synthetic organic chemist. This vast array of products is separated into two major categories: homogeneous a...
ChemFiles Volume 1 Article 3

Transition-Metal Catalysts

A variety of transition-metal catalysts for the Suzuki coupling reaction are now available in our catalog. The majority of these catalysts are palladium- and nickelbased, typically utilizing phosphin...
ChemFiles Volume 1 Article 1
Keywords: Coupling reactions, Ligands, Suzuki coupling

Related Content

Application Guide for Palladium Catalyzed Cross-Coupling Reactions

Palladium catalyzed cross-coupling reactions have revolutionized the way in which molecules are constructed. From the fields of organic synthesis and medicinal chemistry, to materials science and pol...
Keywords: Catalysis, Coupling reactions, Cross couplings, Materials Science, Medicinal chemistry, Organic synthesis, Polymer science, transformation

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