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222410 Sigma-Aldrich

5-Methylindole

99%

Synonym: NSC 522562

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Properties

Related Categories Building Blocks, C7 to C9, Chemical Synthesis, Heterocyclic Building Blocks, Indoles More...
InChI Key   YPKBCLZFIYBSHK-UHFFFAOYSA-N
assay   99%
mp   60-62 °C (lit.)

Description

General description

The binding of 5-methylindole (inducer) to the Escherichia coli trp repressor has been studied. The mass analyzed threshold ionization spectra of jetcooled 5-methylindole (5MI) has also been studied.

Application

Reactant for preparation of:
• Pharmaceutically active 2-oxo-1-pyrrolidine analogues
• Potential anticancer immunomodulators
• Preparation of antifungal agents
• Sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes
• IL2-inducible T-cell kinase (ITK) inhibitors
• Checkpoint 1 kinase inhibitors
• CRTh2 antagonists
• Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment
• Agonists of the histamine H4 receptor
• Monoamine reuptake inhibitors

Packaging

1 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Indoles

Sigma-Aldrich is proud to offer a new series of ChemFiles—called Privileged Structures, to our Drug Discovery and Organic Synthesis customers. Each piece will highlight a specific motif, selected app...
Chemfiles Volume 4 Article 8
Keywords: Building blocks, Cardiovascular, Diabetes, Diseases, Drug discovery, Medicinal chemistry, Organic synthesis, Respiratory

Peer-Reviewed Papers
15

References

Related Products

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