• USA Home
  • 226084 - (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

EMAIL THIS PAGE TO A FRIEND
226084 Sigma-Aldrich

(Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

97%

Synonym: BOP Reagent, BOP, Castros reagent

  • CAS Number 56602-33-6

  • Empirical Formula (Hill Notation) C12H22F6N6OP2

  • Molecular Weight 442.28

  •  Beilstein/REAXYS Number 4287025

  •  EC Number 260-279-1

  •  MDL number MFCD00011948

  •  PubChem Substance ID 24853542

  •  NACRES NA.22

Purchase

Properties

Related Categories Chemical Biology, Chemical Synthesis, Coupling, Peptide Coupling, Peptide Synthesis and Peptide Chemistry,
assay   97%
application(s)   peptide synthesis: suitable
mp   >130 °C (dec.) (lit.)
storage temp.   2-8°C
SMILES string   F[P-](F)(F)(F)(F)F.CN(C)[P+](On1nnc2ccccc12)(N(C)C)N(C)C
InChI   1S/C12H22N6OP.F6P/c1-15(2)20(16(3)4,17(5)6)19-18-12-10-8-7-9-11(12)13-14-18;1-7(2,3,4,5)6/h7-10H,1-6H3;/q+1;-1
InChI key   MGEVGECQZUIPSV-UHFFFAOYSA-N

Description

Application

Reagent for:
Peptide coupling
Synthesis of esters
Esterification of carboxylic acids
Plasmid CAN-encapsulating liposomes
Synthesis of magnolamide for antioxidative activity

Catalyst for preparation of 9-acridinecaroboxamide derivative

Packaging

1, 5 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Supplemental Hazard Statements 
EUH044
Personal Protective Equipment 
RIDADR 
UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., HI: all
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Phosphonium Salts

Phosphonium salts are powerful and easy-to-use peptide coupling reagents that allow in situ generation of active esters. After the recognition of chlorotris(dimethylamino)phosphonium as the activatin...
Matthias Junkers
ChemFiles 2007, 7.2, 8.
Keywords: Peptide synthesis

Related Content

COMU – Safer and More Efficient Peptide Coupling Reagent

Peptide synthesis relies heavily on efficient and reliable coupling reagents. A low tendency for racemization is a key requirement. This is especially true for solid phase peptide synthesis—quantitat...
Keywords: Building blocks, Calorimetry, Condensations, Coupling reactions, Epimerizations, PEGylations, Peptide synthesis, Racemizations, Solid phase peptide synthesis, Solvents

Indoles, Purines, and Their Isosteres

Substituted indoles and purines have frequently been referred to as “privileged structures” since they are capable of binding to multiple receptors with high affinity, and thus have applications acro...
Keywords: Building blocks, Medicinal chemistry

Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

08168 Timestrip Plus 8 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?