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232726 Aldrich

8-Methoxypsoralen

99%

Synonym: 8-MOP, 9-Methoxyfuro[3,2-g][1]benzopyran-7-one, Ammoidin, Methoxsalen, Xanthotoxin

  • CAS Number 298-81-7

  • Empirical Formula (Hill Notation) C12H8O4

  • Molecular Weight 216.19

  •  Beilstein Registry Number 196453

  •  EC Number 206-066-9

  •  MDL number MFCD00005009

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Properties

InChI Key   QXKHYNVANLEOEG-UHFFFAOYSA-N
assay   99%
mp   148-150 °C(lit.)

Description

Biochem/physiol Actions

8-methoxypsoralen (8-MOP) plus ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms. Cultured normal human melanocytes treated with 8-methoxypsoralen and irradiated with ultraviolet A (UVA) formed 8-methoxypsoralen-phospholipid photoadducts that could be substituted for diacylglycerol to activate protein kinase C in a cell-free system. 8-MOP is an inactivator of purified reconstituted cytochrome P450. It also inhibits substance P-induced histamine release from substance P-activated rat peritoneal mast cells by suppressing the rise in [Ca2+].

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
WGK Germany 
3
RTECS 
LV1400000
Protocols & Articles
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M3501 8-Methoxypsoralen, analytical standard

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