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233412 Sigma-Aldrich

Ethyl (hydroxyimino)cyanoacetate

97%

Synonym: Ethyl cyano(hydroxyimino)acetate, Ethyl cyanoglyoxalate-2-oxime, Ethyl isonitrosocyanoacetate

  • CAS Number 3849-21-6

  • Linear Formula NCC(=NOH)CO2C2H5

  • Molecular Weight 142.11

  •  Beilstein/REAXYS Number 774783

  •  EC Number 223-351-3

  •  MDL number MFCD00002112

  •  PubChem Substance ID 24853975

  •  NACRES NA.22

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Properties

Related Categories Active Esters/Additives, Building Blocks, Chemical Biology, Chemical Synthesis, Coupling,
assay   97%
mp   130-132 °C (lit.)
SMILES string   CCOC(=O)C(=N\O)\C#N
InChI   1S/C5H6N2O3/c1-2-10-5(8)4(3-6)7-9/h9H,2H2,1H3/b7-4+
InChI key   LCFXLZAXGXOXAP-QPJJXVBHSA-N

Description

Application

Ethyl (hydroxyimino)cyanoacetate has been used as an additive for the carbodiimide-mediated amide bond formation during established peptide synthesis method.For peptide synthesis grade material, please see product 851086.

Packaging

50, 250 g in glass bottle

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Meet Synthia - Retrosynthesis Sofware
Protocols & Articles

Articles

COMU—Safer and More Efficient Peptide Coupling Reagent

Proteins and peptides are ubiquitous in all living systems. The chemical synthesis of peptidic structures for scientific research or drug discovery relies heavily on efficient coupling reagents. This...
Dr. Matthias Junkers
Aldrich Chemfiles, 2010 Volume 10 Article 1
Keywords: Calorimetry, Coupling reactions, Drug discovery, Epimerizations, Microwave synthesis, Peptide synthesis, Racemizations, Reductions, Solid phase peptide synthesis, Solvents

Peer-Reviewed Papers
15

References

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