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235202 Sigma-Aldrich

4-Bromomethyl-7-methoxycoumarin

97%

Synonym: BMC, Br-Mmc

  • CAS Number 35231-44-8

  • Empirical Formula (Hill Notation) C11H9BrO3

  • Molecular Weight 269.09

  •  Beilstein Registry Number 187211

  •  EC Number 252-448-3

  •  MDL number MFCD00006869

  •  PubChem Substance ID 24854087

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Properties

Related Categories Biochemicals and Reagents, Building Blocks, Chemical Synthesis, Coumarins, Fluorescent Labels,
InChI Key   CTENSLORRMFPDH-UHFFFAOYSA-N
assay   97%
mp   213-215 °C (lit.)
solubility   chloroform: soluble 20 mg/mL, clear, colorless to faintly yellow
fluorescence   λex 322 nm; λem 395 nm (after derivatization)

Description

Application

Fluorescent label for fatty acids.

4-Bromomethyl-7-methoxycoumarin has been used:
• as derivatization reagent in determination of 5-fluorouracil (5-FU) in human plasma by HPLC-tandem mass spectrometry
• as derivatization reagent in fluorescence detection of sodium monofluoroacetate (MFA-Na) in biological samples by HPLC
• in the synthesis of new caged derivatives of hydrolysis-resistant 8-bromoadenosine cyclic 3′,5′-monophosphate (8-Br-cAMP) and 8-bromoguanosine cyclic 3′,5′-monophosphate (8-Br-cGMP)
• in TLC and HPLC separation and fluorometric analysis of a wide range of naturally occurring acids, including bile and thromboxane B2

Packaging

1, 5 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 3335
WGK Germany 
3

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Protocols & Articles

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BioFiles 2011, 6.3, 23.
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Peer-Reviewed Papers
15

References

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