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241512 Sigma-Aldrich

Tetrabutylammonium fluoride hydrate

98%

Synonym: TBAF

  • CAS Number 22206-57-1

  • Linear Formula [CH3(CH2)3]4NF·xH2O

  • Molecular Weight 261.46 (anhydrous basis)

  •  MDL number MFCD00149980

  •  PubChem Substance ID 24854487

  •  NACRES NA.22

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Properties

Related Categories Chemical Synthesis, Deprotecting Reagents, Fluoride Sources, Protection and Derivatization, Synthetic Reagents More...
Quality Level   200
assay   98%
mp   62-63 °C (lit.)
SMILES string   O.[F-].CCCC[N+](CCCC)(CCCC)CCCC
InChI   1S/C16H36N.FH.H2O/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;;/h5-16H2,1-4H3;1H;1H2/q+1;;/p-1
InChI key   UQCWXKSHRQJGPH-UHFFFAOYSA-M

Description

General description

Tetrabutylammonium fluoride hydrate is known to be a source of F anion, used in nucleophilic fluorination reactions. It can be made anhydrous typically by heating it around 40 °C under vacuum.

Application

Reactant for preparation of:
• Double clathrate hydrates at high pressures
• Cellulose ethers
• Terminal olefins via dehydrohalogenation reactions
• Neutral and zwitterionic 3-carboranyl thymidine analogues for boron neutron capture therapy

Tetrabutylammonium fluoride hydrate can be used:
• To prepare 2,7-diethynyl-9-propyl-9H-carbazole, which is a key intermediate for the synthesis of calix[4]arene−carbazole polymers.
• As an anion source in the study of selective detection of F by anion receptor viz Schiff base.
• To prepare terminal olefins from primary alkyl iodides

Packaging

10, 100 g in poly bottle

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3261 8 / PGII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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