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263443 Sigma-Aldrich

1-Bromo-2,4-difluorobenzene

98%

  • CAS Number 348-57-2

  • Linear Formula BrC6H3F2

  • Molecular Weight 192.99

  •  Beilstein Registry Number 1680892

  •  EC Number 206-479-4

  •  MDL number MFCD00000330

  •  PubChem Substance ID 24855973

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Properties

Related Categories Aryl, Aryl Fluorinated Building Blocks, Building Blocks, C6, Chemical Synthesis,
InChI Key   MGHBDQZXPCTTIH-UHFFFAOYSA-N
assay   98%
refractive index   n20/D 1.505(lit.)
bp   145-146 °C(lit.)
mp   −4 °C (lit.)
density   1.708 g/mL at 25 °C(lit.)

Description

Packaging

25, 100 g in glass bottle

Application

1-Bromo-2,4-difluorobenzene has been used in:
• preparation of (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-sila-ethoxy)-propan-1-one
• enantiomeric preparation of the key intermediate of chiral azole antifungal agents by a chemoenzymatic process

General description

1-Bromo-2,4-difluorobenzene undergoes lithiation exclusively at the position having two adjacent halogen substituents, to yield 6-bromo-2,3-difluorobenzoic acid.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 1993C 3 / PGIII
WGK Germany 
3
Flash Point(F) 
125.6 °F
Flash Point(C) 
52 °C

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Protocols & Articles
Peer-Reviewed Papers
15

References

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